Antigen-specific human T-cell hybridomas with helper activity.

نویسندگان

  • E C DeFreitas
  • S Vella
  • A Linnenbach
  • C Zmijewski
  • H Koprowski
  • C M Croce
چکیده

Human T cell hybridomas were produced by fusing the hypoxanthine phosphoribosyltransferase-deficient line of the human T cell lymphoma Jurkat with a continuous line of normal human T cells specific for tetanus toxoid (TeT). The hybridomas were selected for their ability to produce interleukin 2 after exposure to TeT on semiautologous monocytes and for their ability to bind to TeT-pulsed semiautologous monocytes. These antigen-specific T hybridomas demonstrated potent helper activity for semiautologous B cells as determined by the production of high levels of anti-TeT antibody in vitro.

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عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 79 21  شماره 

صفحات  -

تاریخ انتشار 1982